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The Stoppel Lab focuses on topics related to:

• Biomaterial design and development using natural biopolymers
• ​Investigation of evolutionary mechanisms that connect silk production mechanisms in insects in collaboration with the Kawahara Lab at the Florida Museum of Natural History and the McGuire Center for Lepidoptera and Biodiversity at UF
• Development of bioactive molecule delivery systems as solutions to current healthcare challenges, including injectable and implantable materials
• Investigation and leveraging of biodiversity to identify and harness the potential utility of non-commercialized biopolymers from insects for applications in healthcare and medicine
• Quantification and optimization of transport and kinetics within 3D biomaterial systems for predicting and controlling in vivo performance
• Muscle regeneration and methods for generating engineered tissues
• Designing materials to alter wound healing and disease progression

Stoppel Lab, Spring 2020

​Publications

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​Publications from the Stoppel Lab and Dr. Stoppel

1. Shama KA, Turner MA, Broadaway HB, Aikman EL, Stoppel WL, Taylor BL. Advances in Tissue Engineering Approaches for Repairing and Rehabilitating the Myotendinous Junction. Current Opinion in Biomedical Engineering. 2024;30:100532. 
2. Aikman EL, Rao AP, Jia Y, Fussell EE, Trumbull KE, Sampath J, Stoppel WL. Impact of crystalline domains on long-term stability and mechanical performance of anisotropic silk fibroin sponges. J Biomed Mater Res A. 2024;n/a(n/a). Epub 20240312. PubMed PMID: 38469675.
3. Shirk BD, Torres Pereira Meriade Duarte I, McTyer JB, Eccles LE, Lateef AH, Shirk PD, Stoppel WL. Harvesting Silk Fibers from Plodia interpunctella: Role of Environmental Rearing Conditions in Fiber Production and Properties. ACS Biomater Sci Eng. 2024;10(4):2088-99. Epub 20240301. PubMed PMID: 38427786.
4. Pacheco MO, Lutz HM, Armada J, Davies NA, Gerzenshtein IK, Cakley AS, Spiess BD, Stoppel WL. Silk Fibroin Particles as Carriers in the Development of Hemoglobin-Based Oxygen Carriers. Advanced NanoBiomed Research, 2023, 2300019. 
5. Pacheco MO, Eccles LE, Davies NA Armada J, Cakley AS, Kadambi IP, Stoppel WL. Progress in silk and silk fiber-inspired polymeric nanomaterials for drug delivery. Frontiers in Chemical Engineering: Special Topic: Women in Chemical Engineering, 2022, 4. 
6. Jameson JF, Pacheco MO, Bender EC, Kotta NM, Black, III LD, Kaplan DL, Grasman JM, and Stoppel WL. Impact of bioactive molecule inclusion in lyophilized silk scaffolds varies between in vivo and in vitro assessments. Submitted and posted to bioRxiv. (2022).
7. Watson MC, Williams C, Wang RM, Perreault LR, Sullivan KE, Stoppel WL, Black LD. Extracellular matrix and cyclic stretch alter fetal cardiomyocyte proliferation and maturation in a rodent model of heart hypoplasia. Frontiers in Cardiology. 2022. Nov 28;9:993310. 
8. Peeples JK, Jameson JF, Kotta NM, Grasman JM, Stoppel WL, Zare A. Jointly Optimized Spatial Histogram UNET Architecture (JOSHUA) for Adipose Tissue Segmentation. BME Frontiers, 2022, 9854084 (2022) (also available on bioRxiv). 
9. Porter EC, Stoppel WL, Kudej RK, Black LD III. Right ventricular outflow tract surgical resection in young, large animal model for the study of alternative cardiovascular patches. Methods Mol Bio. 2485:299-309 (2022).
10. Jameson JF, Pacheco MO, Nguyen HH, Phelps EA, Stoppel WL. Recent Advances in Natural Materials for Corneal Tissue Engineering. Bioengineering (Basel). 8(11):161, (2021). 
11. Jameson JF, Pacheco MO, Butler JE, Stoppel WL. Estimating Kinetic Rate Parameters for Enzymatic Degradation of Lyophilized Silk Fibroin Sponges. Frontiers in Bioengineering and Biotechnology 9, 537 (2021). Invited as part of a special issue on Silk-Based Functional Biomaterials
12. Barton ER, Pacak CA, Stoppel WL, Kang PB. The ties that bind: functional clusters in limb girdle muscular dystrophy. Skeletal Muscle, 10, 22 (2020). 
13. Kukla DA, Stoppel WL, Kaplan DL, Khetani SR. Assessing the compatibility of primary human hepatocyte culture within porous silk sponges. RSC Advances, 10, 62 (2020). Also available on bioRxiv
14. Tozzi L, Laurent PA, Di Buduo CA, Mu X, Massaro A, Bretherton R, Stoppel W, Kaplan DL, Balduini A. Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production. Biomaterials, 178 (2018).  
15. Noshadi I, Hong S, Sullivan KE, Shirzaei Sani E, Portillo-Lara R, Tamayol A, Shin SR, Gao AE, Stoppel WL, Black LD, III, Khademhosseini A, Annabi N. In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels. Biomaterials Science, 5, 10 (2017). 
16. Stoppel WL, Raia N, Kimmerling E, Wang S, Ghezzi CE, Kaplan DL. 2.12 Silk Biomaterials. In: Comprehensive Biomaterials II, edited by Ducheyne P. Oxford: Elsevier. p. 253-78. (2017).
17. Stoppel WL, Gao AE, Greaney AM, Partlow BP, Bretherton RC, Kaplan DL, Black LD, III. Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response. Journal of Biomedical Materials Research: Part A, 104, 12 (2016). 
18. Ameri S, Singh P, D'Angelo R, Stoppel WL, Black LD III, Sonkusale S. Three dimensional graphene scaffold for cardiac tissue engineering and in-situ electrical recording. Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference. (2016).
19. Stoppel WL, Kaplan DL, Black LD, III. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Advanced Drug Delivery Reviews, 98, (2016). 
20. Stoppel WL, Hu D, Domian IJ, Kaplan DL, Black LD, III. Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering. Biomedical Materials, 10, 3, (2015).
21. Williams C, Budina E, Stoppel WL, Sullivan KE, Emani S, Emani SM, Black LD, III. Cardiac extracellular matrix-fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering. Acta Biomaterialia, 14, (2015). 
22. Stoppel WL, Ghezzi CE, McNamara SL, Black LD, 3rd, Kaplan DL. Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine. Annals of Biomedical Engineering, 43, 3 (2015). 
23. Stoppel WL, White JC, Horava SD, Henry AC, Roberts SC, Bhatia SR. Terminal sterilization of alginate hydrogels: efficacy and impact on mechanical properties. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102, 4, (2014). 
24. White JC, Stoppel WL, Roberts SC, Bhatia SR. Addition of perfluorocarbons to alginate hydrogels significantly impacts molecular transport and fracture stress. Journal of Biomedical Materials Research Part A, 101, 2 (2013). 
25. Stoppel WL, Roberts SC. Oxygen Supply for Tissue Engineering. In: Engineering Biomaterials for Regenerative Medicine, edited by Bhatia SK; Springer New York; 2012. p. 41-86.
26. Stoppel WL, White JC, Horava SD, Bhatia SR, Roberts SC. Transport of biological molecules in surfactant-alginate composite hydrogels. Acta Biomaterialia, 7, 11 (2011). 
27. Choudhary S, White JC, Stoppel WL, Roberts SC, Bhatia SR. Gelation behavior of polysaccharide-based interpenetrating polymer network (IPN) hydrogels. Rheologica Acta, 50, 1 (2011).